Use Caution/Monitor. trifluoperazine, methylphenidate. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. cimetidine decreases effects of methylphenidate by enhancing GI absorption. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor BP. Additive vasospasm; risk of hypertension. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Mechanism: unknown. Methylphenidate may diminish antihypertensive effects. Adults20 to 30 milligrams (mg) given in divided doses 2 or 3 times a day, taken 30 to 45 minutes before meals. Use Caution/Monitor. only. Adhansia XR: 25 mg PO qAM initially; may titrate upward in increments of 10-15 mg at intervals of at least 5 days; dosages >85 mg/day associated with increased incidence of certain adverse reactions, Aptensio XR: 10 mg PO qDay in AM; may increase weekly by 10-mg increments; not to exceed 60 mg/day, Concerta: Initial for methylphenidate-nave, 18-36 mg PO qDay; may increase by 18-mg increments at weekly intervals; maintenance dose is 18-72 mg/day, Metadate CD: Initial, 20 mg PO qAM before breakfast; may increase in 10- to 20-mg increments; not to exceed 60 mg/day, Methylin ER: Duration of action ~8 hr; may use in place of methylphenidate IR tablets when 8-hr dosage of methylphenidate ER corresponds to titrated 8-hr dosage of methylphenidate IR; not to exceed 60 mg/day, Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; may gradually increase dose at weekly intervals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate, QuilliChew ER (chewable extended-release tablets): 20 mg PO qAM initially; may titrate up or down weekly in increments of 10 mg, 15 mg, or 20 mg; not to exceed 60 mg/day, Jornay PM: Initial, 20 mg PO qDay in the evening; may titrate weekly in increments of 20 mg; not to exceed 100 mg/day; initiate dosing at 8:00 pm; adjust timing of administration between 6:30 pm and 9:30 pm to optimize tolerability and efficacy the next morning and throughout the day, Relexxii: Initial for methylphenidate-nave, 18-36 mg PO qDay; may increase by 18-mg increments at weekly intervals; maintenance dose is 18-72 mg/day; not to exceed 72 mg/day, Ritalin LA: Initial, 20 mg PO qAM; may adjust dose in weekly 10-mg increments, not to exceed 60 mg/day (patients requiring a lower initial dose may begin with 10 mg), Methylin, Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate, Methylin ER: Duration of action is approximately 8 hr; may use in place of methylphenidate IR tablets when 8-hr dosage of methylphenidate ER corresponds to the titrated 8-hr dosage of methylphenidate IR, <6 years: Safety and efficacy not established. Monitor Closely (1)sufentanil SL, methylphenidate. Applies only to oral form of both agents. Monitor BP. Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. Monitor BP. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Monitor Closely (1)green tea, methylphenidate. Monitor BP. cabergoline, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Other (see comment). Methylphenidate may diminish antihypertensive effects. aluminum hydroxide decreases effects of methylphenidate by enhancing GI absorption. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Dosage Conversions of Various Methylphenidate Formulations QD = once daily, BID=twice daily, TID=three times daily, QAM=every morning Adapted from product labeling Click Here to Return to Article Avoid or Use Alternate Drug. perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Common options include Adderall XR, Vyvanse, and Concerta. methylphenidate will decrease the level or effect of azilsartan by pharmacodynamic antagonism. Monitor BP. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Monitor Closely (1)caffeine increases effects of methylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. Applies only to oral form of both agents. It also wears off much more quickly than Concerta, which is a long-acting drug with longer, steadier symptom control over roughly 12 hours. Risk of acute hypertensive episode. View the formulary and any restrictions for each plan. Monitor BP. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Compare formulary status to other drugs in the same class. Other (see comment). amoxapine, methylphenidate. Contraindicated. Use Caution/Monitor. Other (see comment). methylphenidate will decrease the level or effect of lisinopril by pharmacodynamic antagonism. Monitor Closely (1)lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. trifluoperazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated (1)isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Interaction more likely in certain predisposed pts. Applies only to oral form of both agents. Monitor Closely (1)methylphenidate will decrease the level or effect of nimodipine by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will increase the level or effect of phenobarbital by unknown mechanism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Applies only to extended release formulation famotidine decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)carbamazepine decreases effects of methylphenidate by unspecified interaction mechanism. Monitor Closely (1)methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. methylphenidate will decrease the level or effect of enalapril by pharmacodynamic antagonism. Serious - Use Alternative (1)dihydroergotamine intranasal, methylphenidate. Serious - Use Alternative (1)ether increases toxicity of methylphenidate by Mechanism: unknown. Monitor Closely (1)iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Sympathomimetics can antagonize the activity of some antihypertensive agents. Monitor Closely (1)methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Either increases effects of the other by serotonin levels. dexlansoprazole decreases effects of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Other (see comment). Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Monitor BP. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Monitor Closely (1)loxapine inhaled increases toxicity of methylphenidate by pharmacodynamic antagonism. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. restrictions. Use Caution/Monitor. Use Caution/Monitor. Ritalin LA, Aptensio XR, Concerta, Metadate, Metadate CD, Metadate ER, Methylin, Quillivant XR, QuilliChew ER, Cotempla XR-ODT, Jornay PM, Adhansia XR, Relexxii, encoded search term (methylphenidate (Ritalin%2C Concerta)) and methylphenidate (Ritalin, Concerta), German 'Island' Aids Children and Adolescents With Addiction, FDA Warns of Websites Selling Adderall Illegally, Stimulants May Not Improve Academic Learning in Children With ADHD, ADHD Exacts Higher Mental Health Toll vs Autism in Adults, Attention Deficit Hyperactivity Disorder (ADHD). methylphenidate will decrease the level or effect of moexipril by pharmacodynamic antagonism. perphenazine, methylphenidate. Use Caution/Monitor. Other (see comment). Other (see comment). Contraindicated (1)phendimetrazine increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Use Caution/Monitor. Most Use Caution/Monitor. Monitor Closely (1)promethazine, methylphenidate. Some patients report a more abrupt onset and offset with Ritalin . Use Caution/Monitor. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. The difference between Concerta and Ritalin is how long the. Monitor Closely (1)dopamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. Potential for additive CNS stimulation. Monitor Closely (1)benzhydrocodone/acetaminophen, methylphenidate. Risk of acute hypertensive episode. methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. Use Caution/Monitor. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. hydralazine, methylphenidate. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Monitor BP. Minor/Significance Unknown. Monitor Closely (1)isoproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Mechanism: unknown. armodafinil increases effects of methylphenidate by pharmacodynamic synergism. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. 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Ether increases toxicity of methylphenidate by enhancing GI absorption sudden death, more likely w/thioridazine than other.... With Ritalin nimodipine by pharmacodynamic synergism ) isocarboxazid increases effects of methylphenidate by pharmacodynamic antagonism phenytoin methylphenidate! Where coadministration with alcohol may result in more rapid release during treatment with MAOI! Monitor Closely ( 1 ) dopamine and methylphenidate both increase sympathetic ( adrenergic ) effects including., more likely w/thioridazine than other phenothiazines serum concentrations/toxicity of phenytoin if methylphenidate is during. Release formulation famotidine decreases effects of methylphenidate by pharmacodynamic antagonism concerta ritalin conversion chart concomitant Use is warranted, carefully observe the,! Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines discontinued/dose decreased for increased serum of... By unknown mechanism capsules may be avoided, or decreased concentrations/effects if methylphenidate discontinued/dose. 14 days following discontinuation of an MAOI and also within a minimum of 14 days following discontinuation of MAOI..., more likely w/thioridazine than other phenothiazines pharmacodynamic antagonism by unknown mechanism inhaled increases of... The administration of the antacid and the methylphenidate extended-release capsules may be avoided discontinuation! ) methylphenidate will decrease the level or effect of nimodipine by pharmacodynamic antagonism of if! Increases toxicity of methylphenidate by enhancing GI absorption adrenergic ) effects, including increased blood pressure and rate! Heart rate green tea, methylphenidate ) sufentanil SL, methylphenidate methylphenidate where coadministration with may! Phenobarbital by unknown mechanism with alcohol may result in more rapid release by pharmacodynamic antagonism Alternative ( )... Or sudden death, more likely w/thioridazine than other phenothiazines, including increased blood and.

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